Our medical and scientific team continues research to improve therapies and offer additional treatment options. Contact a BioXcellerator Patient Advocate to see if new treatments are available for your condition.

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Degenerative Disc Disease

How Can Stem Cells Treat Degenerative Disc Disease?

Degenerative disc disease (DDD), a common aging-related condition, is caused when the discs in your neck and spine—located between bones—begin to shrink and deteriorate as they become dehydrated. This can lead to pain, inflammation, and even bone spurs. Pain resulting from degenerative disc disease can be debilitating and severe, making it uncomfortable to sit, stand, bend over, squat, twist, and participate in your favorite recreational activities—even simply to get a good night’s sleep.

Additional symptoms include tingling, numbness, and weakness throughout the body; lack of coordination; and sciatic symptoms. Without treatment, more bone-on-bone contact can lead to future complications requiring increased pharmaceutical or surgical intervention. Other treatment options can include medications such as corticosteroids that can cause side effects. And in some cases, surgery may be recommended but comes with risk.

See if stem cell treatment is right for you.

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Stem Cell Therapy Can Help To:

  • Promote healing
  • Alleviate chronic neck and back pain
  • Regenerate damaged disc tissue
  • Reduce other symptoms
  • Improve overall quality of life

World Leader in Stem Cell Therapy

Advanced stem cell therapy offers new hope to some patients with spine and disc conditions when standard treatments such as medications or surgery may provide only temporary relief or no relief at all. Find out how a personalized treatment program designed in consultation with our experts can help:

  • Promote healing
  • Reduce inflammation
  • Decompress bulging discs
  • Heal herniated discs
  • Help heal spine and disc injuries in some cases without surgery or medications
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Don’t Settle for a Future Filled with Pain.

Discover how treatment from BioXcellerator can amplify the body’s natural healing and regenerative processes to reduce inflammation, heal damaged tissue, and ease pain.

Citations and Scientific References

Our medical team takes pride in our reputation for collaborating with other scientists worldwide on research studies and established scientific publications. Review these published studies that support the science of our treatment protocols.

  • Navani A, Manchikanti L, Albers SL, Latchaw RE, Sanapati J, Kaye AD, Atluri S, Jordan S, Gupta A, Cedeno D, Vallejo A, Fellows B, Knezevic NN, Pappolla M, Diwan S, Trescot AM, Soin A, Kaye AM, Aydin SM, Calodney AK, Candido KD, Bakshi S, Benyamin RM, Vallejo R, Watanabe A, Beall D, Stitik TP, Foye PM, Helander EM, Hirsch JA. Responsible, Safe, and Effective Use of Biologics in the Management of Low Back Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines. Pain Physician. 2019 Jan;22(1S):S1-S74.
  • Leung, V. Y., Aladin, D. M., Lv, F., Tam, V., Sun, Y., Lau, R. Y., Hung, S. C., Ngan, A. H., Tang, B., Lim, C. T., Wu, E. X., Luk, K. D., Lu, W. W., Masuda, K., Chan, D., & Cheung, K. M. (2014). Mesenchymal stem cells reduce intervertebral disc fibrosis and facilitate repair. Stem cells (Dayton, Ohio), 32(8), 2164–2177. Available from: https://doi.org/10.1002/stem.1717
  • Lykov, A. P., Bondarenko, N. A., Poveshchenko, O. V., Kim, I. I., Surovtseva, M. A., Sadykova, J. B., Semin, P. A., Zavjalov, E. L., Krivoshapkin, A. L., & Konenkov, V. I. (2020). Treatment of Intervertebral Disc Degeneration in Wistar Rats with Mesenchymal Stem Cells. Bulletin of experimental biology and medicine, 168(4), 578–582. Available from: https://doi.org/10.1007/s10517-020-04756-2
  • Croft, A. S., Illien-Jünger, S., Grad, S., Guerrero, J., Wangler, S., & Gantenbein, B. (2021). The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc. International journal of molecular sciences, 22(7), 3519. Available from: https://doi.org/10.3390/ijms22073519
  • Wei, A., Shen, B., Williams, L., & Diwan, A. (2014). Mesenchymal stem cells: potential application in intervertebral disc regeneration. Translational pediatrics, 3(2), 71–90. Available from: https://doi.org/10.3978/j.issn.2224-4336.2014.03.05
  • Ekram, S., Khalid, S., Bashir, I., Salim, A., & Khan, I. (2021). Human umbilical cord-derived mesenchymal stem cells and their chondroprogenitor derivatives reduced pain and inflammation signaling and promote regeneration in a rat intervertebral disc degeneration model. Molecular and cellular biochemistry, 476(8), 3191–3205. Available from: https://doi.org/10.1007/s11010-021-04155-9
  • Sanapati J, Manchikanti L, Atluri S, Jordan S, Albers SL, Pappolla MA, Kaye AD, Candido KD, Pampati V, Hirsch JA. Do Regenerative Medicine Therapies Provide Long-Term Relief in Chronic Low Back Pain: A Systematic Review and Metaanalysis. Pain Physician. 2018 Nov;21(6):515-540.
  • Migliorini, F., Rath, B., Tingart, M., Baroncini, A., Quack, V., & Eschweiler, J. (2019). Autogenic mesenchymal stem cells for intervertebral disc regeneration. International orthopaedics, 43(4), 1027–1036. Available from: https://doi.org/10.1007/s00264-018-4218-y
  • Widjaja, G., Jalil, A. T., Budi, H. S., Abdelbasset, W. K., Efendi, S., Suksatan, W., Rita, R. S., Satria, A. P., Aravindhan, S., Saleh, M. M., Shalaby, M. N., & Yumashev, A. V. (2022). Mesenchymal stromal/stem cells and their exosomes application in the treatment of intervertebral disc disease: A promising frontier. International immunopharmacology, 105, 108537. Available from: https://doi.org/10.1016/j.intimp.2022.108537
  • Vadalà, G., Ambrosio, L., Russo, F., Papalia, R., & Denaro, V. (2019). Interaction between Mesenchymal Stem Cells and Intervertebral Disc Microenvironment: From Stem Cell Therapy to Tissue Engineering. Stem cells international, 2019, 2376172. Available from: https://doi.org/10.1155/2019/2376172
  • Vadalà, G., Russo, F., Ambrosio, L., Papalia, R., & Denaro, V. (2016). Mesenchymal stem cells for intervertebral disc regeneration. Journal of biological regulators and homeostatic agents, 30(4 Suppl 1), 173–179.
  • Richardson, S. M., Kalamegam, G., Pushparaj, P. N., Matta, C., Memic, A., Khademhosseini, A., Mobasheri, R., Poletti, F. L., Hoyland, J. A., & Mobasheri, A. (2016). Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration. Methods (San Diego, Calif.), 99, 69–80. Available from: https://doi.org/10.1016/j.ymeth.2015.09.015
  • Centeno, C., Markle, J., Dodson, E., Stemper, I., Williams, C. J., Hyzy, M., Ichim, T., & Freeman, M. (2017). Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy. Journal of translational medicine, 15(1), 197. Available from: https://doi.org/10.1186/s12967-017-1300-y
  • Noriega, D. C., Ardura, F., Hernández-Ramajo, R., Martín-Ferrero, M. Á., Sánchez-Lite, I., Toribio, B., Alberca, M., García, V., Moraleda, J. M., González-Vallinas, M., Sánchez, A., & García-Sancho, J. (2021). Treatment of Degenerative Disc Disease With Allogeneic Mesenchymal Stem Cells: Long-term Follow-up Results. Transplantation, 105(2), e25–e27. Available from: https://doi.org/10.1097/TP.0000000000003471
  • Liao, Z., Luo, R., Li, G., Song, Y., Zhan, S., Zhao, K., Hua, W., Zhang, Y., Wu, X., & Yang, C. (2019). Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo. Theranostics, 9(14), 4084–4100. Available from: https://doi.org/10.7150/thno.33638
  • Xia, C., Zeng, Z., Fang, B., Tao, M., Gu, C., Zheng, L., Wang, Y., Shi, Y., Fang, C., Mei, S., Chen, Q., Zhao, J., Lin, X., Fan, S., Jin, Y., & Chen, P. (2019). Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and antiinflammatory effects. Free radical biology & medicine, 143, 1–15. Available from: https://doi.org/10.1016/j.freeradbiomed.2019.07.026
  • Zhao, Y., Qin, Y., Wu, S., Huang, D., Hu, H., Zhang, X., & Hao, D. (2020). Mesenchymal stem cells regulate inflammatory milieu within degenerative nucleus pulposus cells via p38 MAPK pathway. Experimental and therapeutic medicine, 20(5), 22. Available from: https://doi.org/10.3892/etm.2020.9150
  • Zhao, Y. T., Qin, Y., Yang, J. S., Huang, D. G., Hu, H. M., Wang, X. D., Wu, S. F., & Hao, D. J. (2020). Wharton’s Jelly-derived mesenchymal stem cells suppress apoptosis of nucleus pulposus cells in intervertebral disc degeneration via Wnt pathway. European review for medical and pharmacological sciences, 24(19), 9807–9814. Available from: https://doi.org/10.26355/eurrev_202010_23190
  • Richardson, S. M., Hoyland, J. A., Mobasheri, R., Csaki, C., Shakibaei, M., & Mobasheri, A. (2010). Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering. Journal of cellular physiology, 222(1), 23–32. Available from: https://doi.org/10.1002/jcp.21915
  • Zeckser, J., Wolff, M., Tucker, J., & Goodwin, J. (2016). Multipotent Mesenchymal Stem Cell Treatment for Discogenic Low Back Pain and Disc Degeneration. Stem cells international, 2016, 3908389. Available from: https://doi.org/10.1155/2016/3908389
  • Yim, R. L., Lee, J. T., Bow, C. H., Meij, B., Leung, V., Cheung, K. M., Vavken, P., & Samartzis, D. (2014). A systematic review of the safety and efficacy of mesenchymal stem cells for disc degeneration: insights and future directions for regenerative therapeutics. Stem cells and development, 23(21), 2553–2567. Available from: https://doi.org/10.1089/scd.2014.0203

Find out if treatment is right for you. Schedule a free consultation with one of our experts today.

Signature Cells

Proprietary Protocols. Based on Advanced Science.

The most effective stem cell therapy starts with the best possible cells. BioXcellerator Signature Cells are produced from mesenchymal stem cells (MSCs) derived from Wharton’s jelly umbilical cord tissue.

Based on our proprietary protocols, these cells are cultured and expanded in our on-site lab and tested to make sure they meet high standards for purity and potency, and demonstrate:

  • High levels of anti-inflammatory properties
  • Best potential to modulate your immune system
  • More potential to stimulate healing

Discover how Signature Cells and our advanced treatment protocols can promote healing of spine and disc conditions and relieve back and neck pain.

Real People. Real Results.

Meet patients who now enjoy better health, more energy, and less pain thanks to advanced stem cell therapy for spine and disc conditions.

Nicolas Jones

BioXcellerator Patient

Treated for Degenerative Disc Disease

James Stewart

BioXcellerator Patient

Treated for Degenerative Disc Disease

Aaron Sage

BioXcellerator Patient

Treated for Degenerative Disc Disease

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