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Mesenchymal Stem Cell Therapy in Patients With Diabetes: A Comprehensive Systema...
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Safety and Efficacy of Mesenchymal Stem Cell Therapy in Erectile Dysfunction ...
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Do Maternal and Fetal Demographics Affect the Quality of Umbilical Cord-Derived ...
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Safety and Efficacy of Mesenchymal Stem Cell Therapy in Adults With Inflammatory...
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Hypoxia-Induced Metabolic Reprogramming in Mesenchymal Stem Cells: Unlocking the...
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Safety Profile of MSCs Therapy Administered Through Intrathecal Injections for N...
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February 19, 2024
MSCs for Spinal Cord Injury
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MSCs for Knee Osteoarthritis
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Citations and Scientific References
Orthopedic
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Osteoarticular Conditions and Degenerative Disc Disease
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- Wang, A. T., Feng, Y., Jia, H. H., Zhao, M., & Yu, H. (2019). Application of mesenchymal stem cell therapy for the treatment of osteoarthritis of the knee: A concise review. World journal of stem cells, 11(4), 222–235. Available from: https://doi.org/10.4252/wjsc.v11.i4.222
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- Liang, H., Suo, H., Wang, Z., & Feng, W. (2020). Progress in the treatment of osteoarthritis with umbilical cord stem cells. Human cell, 33(3), 470–475. Available from: https://doi.org/10.1007/s13577-020-00377-z
- Wang, H., Yan, X., Jiang, Y., Wang, Z., Li, Y., & Shao, Q. (2018). The human umbilical cord stem cells improve the viability of OA degenerated chondrocytes. Molecular medicine reports, 17(3), 4474–4482. Available from: https://doi.org/10.3892/mmr.2018.8413
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- Song, Y., Zhang, J., Xu, H., Lin, Z., Chang, H., Liu, W., & Kong, L. (2020). Mesenchymal stem cells in knee osteoarthritis treatment: A systematic review and meta-analysis. Journal of orthopaedic translation, 24, 121–130. Available from: https://doi.org/10.1016/j.jot.2020.03.015
- Hwang, J. J., Rim, Y. A., Nam, Y., & Ju, J. H. (2021). Recent Developments in Clinical Applications of Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis and Osteoarthritis. Frontiers in immunology, 12, 631291. Available from: https://doi.org/10.3389/fimmu.2021.631291
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- Zhu, C., Wu, W., & Qu, X. (2021). Mesenchymal stem cells in osteoarthritis therapy: a review. American journal of translational research, 13(2), 448–461.
- Han, Y., Li, X., Zhang, Y., Han, Y., Chang, F., & Ding, J. (2019). Mesenchymal Stem Cells for Regenerative Medicine. Cells, 8(8), 886. Available from: https://doi.org/10.3390/cells8080886
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- Leung, V. Y., Aladin, D. M., Lv, F., Tam, V., Sun, Y., Lau, R. Y., Hung, S. C., Ngan, A. H., Tang, B., Lim, C. T., Wu, E. X., Luk, K. D., Lu, W. W., Masuda, K., Chan, D., & Cheung, K. M. (2014). Mesenchymal stem cells reduce intervertebral disc fibrosis and facilitate repair. Stem cells (Dayton, Ohio), 32(8), 2164–2177. Available from: https://doi.org/10.1002/stem.1717
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- Ekram, S., Khalid, S., Bashir, I., Salim, A., & Khan, I. (2021). Human umbilical cord-derived mesenchymal stem cells and their chondroprogenitor derivatives reduced pain and inflammation signaling and promote regeneration in a rat intervertebral disc degeneration model. Molecular and cellular biochemistry, 476(8), 3191–3205. Available from: https://doi.org/10.1007/s11010-021-04155-9
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- Widjaja, G., Jalil, A. T., Budi, H. S., Abdelbasset, W. K., Efendi, S., Suksatan, W., Rita, R. S., Satria, A. P., Aravindhan, S., Saleh, M. M., Shalaby, M. N., & Yumashev, A. V. (2022). Mesenchymal stromal/stem cells and their exosomes application in the treatment of intervertebral disc disease: A promising frontier. International immunopharmacology, 105, 108537. Available from: https://doi.org/10.1016/j.intimp.2022.108537
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- Noriega, D. C., Ardura, F., Hernández-Ramajo, R., Martín-Ferrero, M. Á., Sánchez-Lite, I., Toribio, B., Alberca, M., García, V., Moraleda, J. M., González-Vallinas, M., Sánchez, A., & García-Sancho, J. (2021). Treatment of Degenerative Disc Disease With Allogeneic Mesenchymal Stem Cells: Long-term Follow-up Results. Transplantation, 105(2), e25–e27. Available from: https://doi.org/10.1097/TP.0000000000003471
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Neurodegenerative and Neurological Conditions
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- Albu S, Kumru H, Coll R, Vives J, Vallés M, Benito-Penalva J, Rodríguez L, Codinach M, Hernández J, Navarro X, Vidal J. Clinical effects of intrathecal administration of expanded Wharton jelly mesenchymal stromal cells in patients with chronic complete spinal cord injury: a randomized controlled study. Cytotherapy. 2021 Feb;23(2):146-156
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- Bang OY, Lee JS, Lee PH, Lee G. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol. 2005 Jun;57(6):874-82. Available from: https://doi.org/10.1002/ana.20501
- Jaillard A, Hommel M, Moisan A, Zeffiro TA, Favre-Wiki IM, Barbieux-Guillot M, Vadot W, Marcel S, Lamalle L, Grand S, Detante O; (for the ISIS-HERMES Study Group). Autologous Mesenchymal Stem Cells Improve Motor Recovery in Subacute Ischemic Stroke: a Randomized Clinical Trial. Transl Stroke Res. 2020 Oct;11(5):910-923. Available from: https://doi.org/10.1007/s12975-020-00787-z
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- Perets, N., Segal-Gavish, H., Gothelf, Y., Barzilay, R., Barhum, Y., Abramov, N., Hertz, S., Morozov, D., London, M., & Offen, D. (2017). Long term beneficial effect of neurotrophic factors-secreting mesenchymal stem cells transplantation in the BTBR mouse model of autism. Behavioural brain research, 331, 254–260. Available from: https://doi.org/10.1016/j.bbr.2017.03.047
- Chez, M., Lepage, C., Parise, C., Dang-Chu, A., Hankins, A., & Carroll, M. (2018). Safety and Observations from a Placebo-Controlled, Crossover Study to Assess Use of Autologous Umbilical Cord Blood Stem Cells to Improve Symptoms in Children with Autism. Stem cells translational medicine, 7(4), 333–341. Available from: https://doi.org/10.1002/sctm.17-0042
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Urological Conditions
- Yao C, Zhang X, Yu Z, et al., Effects of Stem Cell Therapy on Diabetic Mellitus Erectile Dysfunction: A Systematic Review and Meta-analysis. J Sex Med 2022;19:21–36.
- Al Demour S, Adwan S, Jafar H, Rahmeh R, Alhawari H, Awidi A. Safety and Efficacy of 2 Intracavernous Injections of Allogeneic Wharton’s Jelly-Derived Mesenchymal Stem Cells in Diabetic Patients with Erectile Dysfunction: Phase 1/2 Clinical Trial. Urol Int. 2021;105(11-12):935- 943.
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Endocrine Conditions
- Solis, M. A., Moreno Velásquez, I., Correa, R., & Huang, L. (2019). Stem cells as a potential therapy for diabetes mellitus: a call-to-action in Latin America. Diabetology & metabolic syndrome, 11, 20. Available from: https://doi.org/10.1186/s13098-019-0415-0
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- Qi, Y., Ma, J., Li, S., & Liu, W. (2019). Applicability of adipose-derived mesenchymal stem cells in treatment of patients with type 2 diabetes. Stem cell research & therapy, 10(1), 274. Available from: https://doi.org/10.1186/s13287-019-1362-2
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Chronic Gastrointestinal Inflammatory Conditions
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- Gallo, G., Tiesi, V., Fulginiti, S., De Paola, G., Vescio, G., & Sammarco, G. (2020). Mesenchymal Stromal Stem Cell Therapy in the Management of Perianal Fistulas in Crohn’s Disease: An Up-To-Date Review. Medicina (Kaunas, Lithuania), 56(11), 563. Available from: https://doi.org/10.3390/medicina56110563
- Grim, C., Noble, R., Uribe, G., Khanipov, K., Johnson, P., Koltun, W. A., Watts, T., Fofanov, Y., Yochum, G. S., Powell, D. W., Beswick, E. J., & Pinchuk, I. V. (2021). Impairment of Tissue-Resident Mesenchymal Stem Cells in Chronic Ulcerative Colitis and Crohn’s Disease. Journal of Crohn’s & colitis, 15(8), 1362–1375. Available from: https://doi.org/10.1093/ecco-jcc/jjab001
- Włodarczyk, M., Czerwińska, K., Włodarczyk, J., Fichna, J., Dziki, A., & Dziki, Ł. (2021). Current Overview on the Use of Mesenchymal Stem Cells for Perianal Fistula Treatment in Patients with Crohn’s Disease. Life (Basel, Switzerland), 11(11), 1133. Available from: https://doi.org/10.3390/life11111133
- Dailey, F. E., Turse, E. P., Naseer, M., Bragg, J. D., & Tahan, V. (2018). Review of stem cells as promising therapy for perianal disease in inflammatory bowel disease. World journal of transplantation, 8(4), 97–101. Available from: https://doi.org/10.5500/wjt.v8.i4.97
- Martínez-Montiel, M., Gómez-Gómez, G. J., & Flores, A. I. (2014). Therapy with stem cells in inflammatory bowel disease. World journal of gastroenterology, 20(5), 1211–1227. Available from: https://doi.org/10.3748/wjg.v20.i5.1211
- Grégoire, C., Lechanteur, C., Briquet, A., Baudoux, É., Baron, F., Louis, E., & Beguin, Y. (2017). Review article: mesenchymal stromal stem cell therapy for inflammatory bowel diseases. Alimentary pharmacology & therapeutics, 45(2), 205–221. Available from: https://doi.org/10.1111/apt.13864
- Shi, X., Chen, Q., & Wang, F. (2019). Mesenchymal stem cells for the treatment of ulcerative colitis: a systematic review and meta-analysis of experimental and clinical studies. Stem cell research & therapy, 10(1), 266. Available from: https://doi.org/10.1186/s13287-019-1336-4
- Hosseini-Asl, S. K., Mehrabani, D., & Karimi-Busheri, F. (2020). Therapeutic Effect of Mesenchymal Stem Cells in Ulcerative Colitis: A Review on Achievements and Challenges. Journal of clinical medicine, 9(12), 3922. Available from: https://doi.org/10.3390/jcm9123922
- Huldani, H., Margiana, R., Ahmad, F., Opulencia, M., Ansari, M. J., Bokov, D. O., Abdullaeva, N. N., & Siahmansouri, H. (2022). Immunotherapy of inflammatory bowel disease (IBD) through mesenchymal stem cells. International immunopharmacology, 107, 108698. Advance online publication. Available from: https://doi.org/10.1016/j.intimp.2022.108698
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- Choi, Y. J., Koo, J. B., Kim, H. Y., Seo, J. W., Lee, E. J., Kim, W. R., Cho, J. Y., Hahm, K. B., Hong, S. P., Kim, D. H., & Yoo, J. H. (2019). Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic activation in human intestinal myofibroblasts via inhibition of myocardin-related transcription factor A. Stem cell research & therapy, 10(1), 291. Available from: https://doi.org/10.1186/s13287-019-1385-8
- Lazebnik, L. B., Kniazev, O. V., Konopliannikov, A. G., Parfenov, A. I., Ruchkina, I. N., Mikhaĭlova, Z. F., Tsaregorodtseva, T. M., Khomeriki, S. G., Rogozina, V. A., Gudkova, R. B., Shcherbakov, P. L., & Konopliannikova, O. A. (2010). Eksperimental’naia i klinicheskaia gastroenterologiia. Experimental & clinical gastroenterology, (11), 3–15.
- Knyazev, O. V., Parfenov, A. I., Konoplyannikov, A. G., & Boldyreva, O. N. (2016). Terapevticheskii arkhiv, 88(2), 44–48. Available from: https://doi.org/10.17116/terarkh201688244-48
Autoimmune Conditions
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- Jiang, W., & Xu, J. (2020). Immune modulation by mesenchymal stem cells. Cell proliferation, 53(1), e12712. Available from: https://doi.org/10.1111/cpr.12712
- Lv, X., Wang, L., Zou, X., & Huang, S. (2021). Umbilical Cord Mesenchymal Stem Cell Therapy for Regenerative Treatment of Rheumatoid Arthritis: Opportunities and Challenges. Drug design, development and therapy, 15, 3927–3936. Available from: https://doi.org/10.2147/DDDT.S323107
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- Sonomoto, K., Yamaoka, K., & Tanaka, Y. (2014). Journal of UOEH, 36(2), 141–146. Available from: https://doi.org/10.7888/juoeh.36.141
- Tanaka, Y., Sonomoto, K., Kondo, M., Oshita, K., Zhang, X. M., Fukuyo, S., & Yamaoka, K. (2015). Nihon Rinsho Men’eki Gakkai kaishi. Japanese journal of clinical immunology, 38(2), 86–92. Available from: https://doi.org/10.2177/jsci.38.86
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- Tanaka Y. (2015). Human mesenchymal stem cells as a tool for joint repair in rheumatoid arthritis. Clinical and experimental rheumatology, 33(4 Suppl 92), S58–S62.
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- El-Jawhari, J. J., El-Sherbiny, Y. M., Jones, E. A., & McGonagle, D. (2014). Mesenchymal stem cells, autoimmunity and rheumatoid arthritis. QJM: monthly journal of the Association of Physicians, 107(7), 505–514. Available from: https://doi.org/10.1093/qjmed/hcu033
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Dermatological Conditions
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Inflammaging and Immunomodulation
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