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“Are Your Medications Harming Your Nerves? Unveiling the Hidden Dangers of Drug-Induced Peripheral Neuropathy”

Chronic Inflammatory Systemic Diseases (CID) are long-lasting conditions that cause inflammation in the body. Some examples include Rheumatoid Arthritis, Inflammatory Bowel Disease, and Systemic Lupus Erythematosus.

Peripheral neuropathy, a condition where nerves outside the brain and spinal cord are damaged, can be a surprising side effect of many commonly prescribed medications. This condition, known as Drug-Induced Peripheral Neuropathy (DIPN), can cause a range of symptoms from mild discomfort to severe pain and disability.

Causes and Risk Factors

The onset of DIPN is often linked to the dosage and duration of medication use. It typically results from primary axonal degeneration, which can be due to toxic reactions or metabolic changes caused by the drugs [1]. Certain groups of people, such as the elderly or those with pre-existing nerve damage, may be at higher risk.

Symptoms and Diagnosis

The symptoms usually involve sensory disturbances in a “glove and stocking” distribution, meaning they affect the hands and feet. Patients may experience numbness, tingling, and burning sensations. In some cases, there can be muscle weakness or even motor involvement, where movement is affected, though this is less common [2].

Medications That Can Cause DIPN

While chemotherapy drugs are a well-known cause of DIPN, various other medications, including some used for treating infections, heart conditions, and even some over-the-counter drugs, can lead to this condition. It’s important to be aware of all medications that have the potential to cause neuropathy.

Treatment and Management

Treatment for DIPN includes medications like duloxetine and gabapentin, which are shown to reduce neuropathic pain [2]. In some cases, stopping or changing the medication causing the neuropathy can lead to improvement. Physical therapy and pain management strategies may also be beneficial.

Prevention and Awareness

Awareness is key to managing DIPN. Patients should be informed about the potential side effects of their medications. Regular monitoring and communication with healthcare providers are crucial, especially for those on long-term medication. If you experience any unusual symptoms while on medication, consulting your healthcare provider is essential. Early detection and adjustment of medication can prevent further nerve damage and improve quality of life.


Understanding the risks and symptoms of DIPN is vital for patients and healthcare providers alike. With proper management and awareness, the impact of this condition can be significantly reduced, ensuring a better quality of life for those affected.


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