All about treatment with stem cells and Regenerative Medicine in Medellín

Advances in medicine and science continue to surprise. In the last decades, treatments with stem cells as part of the cellular therapy of Regenerative Medicine have been the center of studies and research in different scientific fields.

This is summarized in the review article “Regenerative Medicine and stem cells. Mechanisms of action of adult stem cells”, from the Institute of Hematology and Immunology, Havana, Cuba:

" Regenerative medicine is a branch of medicine that has developed considerably in recent years. Advances in this field have been closely linked to new knowledge acquired about stem cells and their ability to become cells from different tissues. This medicine is based on behaviors adopted by the body to replace healthy cells with those damaged by various processes in certain tissues. "

The return of stem cells to the patient's body to treat different diseases and disorders, became a novel and alternative solution to the poor results of traditional medical treatments.

And it is that someone who suffers a disease that has caused pain and discomfort throughout his life and that has affected his normal development, knows what a daily struggle to maintain. How not to try a new treatment that can change your quality of life forever?

This application of stem cells, although it is an outpatient treatment, requires a group of qualified professionals, laboratories and high-tech equipment, and a protocol that meets high safety standards. Something that can only be found in a clinic with approved therapies.

Although stem cells have been used for multiple medical conditions for twenty years, many people still consider these therapies as "new and experimental", but many cases have been identified of patients for whom stem cell therapy has been very cash.

Based on the positive experiences that the medical team of BioXcellerator has known, and the innovation with cell therapy, in the clinic regenerative medical therapies are made to treat various autoimmune, musculoskeletal, neurodegenerative diseases, among others, to bring well-being to our patients .

Clear your doubts: myths and realities about stem cells

Next, we present a broad panorama so that you understand better what Regenerative Medicine is and what is a treatment with stem cells, having as main cede the BioXcellerator clinic, unique in its type in Colombia, located in Medellín.

The human body is made up of hundreds of different types of cells that fulfill specific functions and that are responsible for keeping our body functioning every day. Among these are the stem cells, which are the suppliers of all the new cells that are responsible for the regeneration of tissues, thus maintaining the healthy body.

They are cells that have the ability to divide and differentiate into various types of specialized cells, which makes them a vital element for medical research and treatment.

Stem cells are the providers of new cells. When these are divided, they can make more of themselves or more of other types of cells. For example, they can form more skin stem cells or can form differentiated skin cells that have specific jobs such as producing the melanin pigment.

Stem cells can be obtained from various tissues such as fatty tissue, bone marrow, umbilical cord cells, umbilical cord blood, dental pulp, among others. In cell therapy, these stem cells are expanded and cultured in the Cell Bank of BioXcellerator, obtaining a higher cellular number of high qualities, to be subsequently reintroduced into the individual through different routes, depending on the patient's medical condition.

Cells derived from adipose tissue, bone marrow and umbilical cord have unique advantages such as: easy to obtain, absence of risk of immune rejection, immediate availability, minimal risk of complications, infections and disability.

Stem cells act through the secretion of bioactive molecules. Dr. Arnold Caplan, pioneer in the research of mesenchymal stem cells and adjudicator of his name MSC, proposed to rename these cells as medicinal signaling cells or Medicinal Signaling Cells (MSC) for its acronym in English, because the most important function of these cells they are the factors that they secrete.

THE CHARACTERISTICS AND PROPERTIES OF THE MSC (MEDICINAL SIGNALING CELLS)

• Capacity of numerous cycles of cell division maintaining the undifferentiated state or its capacity for self-renewal.
• They are found in multiple tissues of the body.
• One of its main functions is to maintain cell balance and replace cells that are becoming sick or dying (apoptosis) and under pathological conditions has the potential to regenerate damaged tissue.
• They can generate many types of specialized cells. Being multipotent can be differentiated into a subset of cell types such as bone, cartilage, adipose tissue, muscle, endothelial cells, among others.
• They synthesize and secrete a set of trophic factors (growth factors) that stimulate or activate the patient's own cells, promoting their expansion or proliferation, among other functions.
• They have the ability to migrate to affected areas through inflammatory signals released in pathological conditions (Homming).

STEM CELLS WORK WITH THE FOLLOWING MECHANISMS:

• Stimulation of cell differentiation
• Immunomodulation and inflation control: mesenchymal stem cells have strong anti-inflammatory and immunomodulatory properties. These cells regulate the immune system and reduce inflammation helping in the treatment of autoimmune and inflammatory conditions.
• Signaling: MSCs secrete a large amount of cytokines, chemokines and trophic factors, which stimulate the endogenous MSCs for differentiation, mobilization and proliferation.

TYPES OF STEM CELLS

According to their origin:

• Adults: they are also called somatic and are those that can be extracted from any person, regardless of their age. They can be found in specific areas (MSC niches) of all tissues and parts of the body, staying dormant for long periods until they are activated either to complete the cell renewal cycle, or to repair a damaged tissue due to an illness or an injury.

• Embryonic: are those found in embryos more than four or five days old and from them develop all the tissues and organs of the fetus. Given their very high differentiation capacity, they can be transformed into any type of cell, they are the most interesting from the research perspective, but they raise important ethical questions that have led to prohibiting their use in most countries.

• Perinatal: are those that can be obtained from tissues that are normally discarded after the birth of a baby such as: placenta, umbilical cord, amniotic membrane, amniotic fluid and umbilical cord. Of the cells of the umbilical cord it is necessary to differentiate between those that can be extracted from the cord blood and those of the umbilical cord tissue that are known as Wharton's gelatin cells. The blood cells of the umbilical cord are of hematopoietic origin, therefore, there are differences between their functions and possible utilities.

• Reprogrammed or iPS: these cells are differentiated adults, which are forced to re-express genes associated with embryonic stages, therefore, they return to express characteristics of embryonic stem cells without the ethical conflicts of these cells. Their disadvantage is that they are genetically modified so they can be unstable.
  
  

According to the patient:

• Autologous: That they are characteristic of the same individual.

• Allogenic: Of different individuals of the same species

• Xenogenic: From a different species differentiation

According to their potential:

Totipotent: They have the capacity to form a complete organism. They are not used in cellular therapies.

Pluripotent: They have the potential to develop any type of cell. They are obtained from the blastocyst or by cell reprogramming. They are not used in cellular therapies due to ethical conflicts and genetic instability, respectively. Very used in research. High risk of producing tumors.

Multipotent: They are called organ-specific or adult stem cells capable of generating any type of cell from their germ layer. They are used in cell therapy.

Types of stem cells most used

• Mesenchymal Stem Cell
  
• Hematopoietic Stem Cells 

To understand why stem cells are used to treat diseases and different medical conditions, You must first understand what Regenerative Medicine is.

WHAT IS REGENERATIVE MEDICINE?

Regenerative medicine is a vanguard branch of medicine, which emerges through interdisciplinary research integrating various areas such as: cell biology, tissue engineering, gene therapy, cell therapy, cell immunotherapy, 3D bioprinting, therapy with exosomes, among others, according to the International Society for Stem Cell Research (ISSCR, for its acronym in English).

Regenerative medicine is based on the repair, replacement or regeneration of cells, tissues and / or organs by stimulating and enhancing the self-healing capabilities of the human body. Its fundamental principle is to restore the functionality of the tissues.

BioXcellerator Colombia, is a pioneer institution in the application of cellular therapies that meets the highest standards of quality, human resources, commitment and cutting-edge technologies under the medical direction of Dr. Karolynn Halpert.

STEM CELL THERAPY

It is a process by which new cells are introduced to the body to treat a disease. Cell therapy involves a wide variety of cell types with regenerative, reparative, protective or immunoregulatory characteristics, among which are the so-called stem cells or Stem Cells.

Unlike many traditional treatments, some of high cost, with side effects, which are not directed to the causes but to the symptoms, cell therapy has had very promising and even potentially curable answers. Other countries around the world are already using cell therapy with effective results and research is increasingly hopeful and accurate, however, few clinics have legally approved therapies.

The most commonly used stem cells are the mesenchymal stem cells of Wharton's gelatin from the umbilical cord, bone marrow or stromal, and adipose tissue. For the type of condition or disease to be treated, the medical team should have a broad knowledge of the patient's condition, treatment alternatives and evidence that the steps to follow can offer a successful outcome.

You can also read: FAMOUS SPORTSPEOPLE WHO HAVE USED TREATMENT WITH STEM CELLS

WHY GET A MSC CELL TREATMENTS?

In a natural way, our body has a capacity to repair injuries that diminish as we get older. The quantity and quality of MSC that we all have also decreases with time.

The treatment with MSC consists of supplying the patient with as many cells as possible, thus increasing the body's capacity to protect, replace or regenerate damaged or diseased cells.

ADVANTAGES:

• It has few possibilities to generate rejection by the organism.
• It is an alternative treatment for medical conditions such as degenerative diseases, which do not have effective traditional pharmacological therapies.
• MSCs offer treatments with an important possibility of recovery and improvement of hope and quality of life.
• They can reverse or slow the progression of the disease.
• The MSCs of adipose tissue and bone marrow are obtained through ambulatory and low risk processes, with local anesthesia.
• The Wharton Jelly MSCs of umbilical cord are available at all times in the incubators of the BioXcellerator cell bank, avoiding the patient having to go through some surgical procedure for its extraction.
• They can be used for rejuvenation or anti-aging treatments.

HOW IS THE MEDICAL PROCESS OF THE TREATMENT?

STAGES OF THE TREATMENT WITH MSC

The treatment with MSC is a process that demands advanced technical and technological capacities, and a professional team highly specialized in cellular therapy. Before cell therapy, the BioXcellerator team performs the following procedures to have the cells ready at all times for our patients:

1. Obtaining umbilical cords
2. Extensive safety and quality tests on umbilical cord samples
3. Separation or isolation: procedure by which they separate the MSCs of the tissue
4. Cultivation or expansion: the cells are cultivated in order to increase their number and their purity for the necessary dose in each pathology.
5. Cryopreservation: after expansion, the cells are stored at temperatures of -180oC for conservation and use in future doses, if necessary.

At the time of cell therapy the following steps are followed:

1. Patient evaluation, medical history, diagnostic aids
2. Patient preparation with Biorregulatory Systems Medicine, Functional Medicine, Orthomolecular Medicine and Hyperbaric Medicine.
3. Treatment with cell therapy: Application intravenously, intramuscularly, intraarticularly, intralesionally, intrathecally, intranasally, intradermally, intradiscally, among others according to the needs of the patient.
4. Close and constant monitoring. (1, 3, 6 and 12 months)

How are therapies with stem cells enhanced?

• BioXgel

The majority of therapies in BioXcellerator are complemented with BioXgel (concentration of growth factors) which are responsible for providing nutrients to the cells used and accelerating the natural process of repair, desinflammation and regeneration of tissues.

BioXgel is obtained from a small amount of blood from the same patient, which is processed with high quality standards which allows to have a concentration of these factors.

• Hyperbaric oxygen therapy.
• Oral medications, bioregulators of systems
• IV nutrition, IV Therapy.
• Nutritional recommendations
• Recommendations for post-treatment cellular stimulation.

Stem cells can be used in the treatment of neurological, cardiovascular, pulmonary, urological, autoimmune, musculoskeletal, gastrointestinal, skin disorders, and rejuvenation and anti-aging therapies.

You might be interested: Myths and realities of stem cells.

Thanks to the therapy with MSC, in BioXcellerator the following disorders are treated:

Neurological disorders

• Parkinson's
• disease Alzheimer's disease
• Stroke
• Cerebral palsy
• Autism
• Ataxia
• Spinal cord injuries
• Multiple
• sclerosis Amyotrophic lateral sclerosis
• Cranioencephalic trauma
• Neuropathy
• Encephalopathy traumatic chronic

Cardiovascular disorders

• Congestive heart failure
• Acute myocardial infarction
• Critical ischemia (chronic occlusive arterial disease)

Pulmonary disorders

• COPD
• Asthma
• Pulmonary fibrosis

Urological disorders

• Urinary incontinence
• Erectile dysfunction
• Vaginal rejuvenation
• Point G stimulation

Autoimmune disorders

• Systemic lupus erythematosus
• Rheumatoid arthritis
• Type 1 diabetes

Musculoskeletal disorders

• Osteoarthrosis
• Injuries ligaments, cartilage and bone
• Tendonitis
• Traumas
• Discopathies

Gastrointestinal disorders

• liver Diseases
• Pancreatic diseases (Diabetes Miellitus)

Skin disorders

• Psoriasis
• Burns
• Wounds
• Injuries
• Ulcers
• Diabetic foot

Rejuvenation and anti-aging therapies

• Reduces fine lines.
• It recovers the elasticity and luminosity generating a fresher appearance.
• Regain a youthful, healthy and repaired appearance.
• Feel a healthy skin naturally.

STEM CELLS AND REJUVENATION TREATMENTS

treatment to rejuvenate Stem cell treatments to rejuvenate is one of the most desired by people who are interested in this type of therapy. Indeed, Regenerative Medicine, from stem cells has impacted and influenced the field of Aesthetic Medicine, where perhaps some of the most incredible solutions are found.

The ability of stem cells to renew, repair and regenerate tissues, gives them a great advantage as antiaging treatment, so this therapy has become so popular and more and more are opting for this simple, natural and effective alternative.

To qualify as suitable, certain factors must be evaluated such as the physiological condition of the patient, the current state of his illness. Our scientific medical committee is the one who decides whether a patient can or cannot receive treatment. We will not offer the treatment if we believe that there is potential danger no matter how insignificant, or if it is considered that the therapy will not provide any benefit.

We invite you to read: Questions and answers about treatments with stem cells

"The treatments with stem cells are specific for each patient. The same treatment can have different results among them, "says Karolynn Halpert, medical director of BioXcellerator.

Another exclusion criterion is patients with cancer or with a high risk of cancer. In turn, stem cells are not used in pregnant women.

Do you have questions about stem cell treatments? We answer them

Treatments with stem cells do not represent a definitive cure to the aforementioned diseases. However, they allow advances in hope and quality of life:

• They allow a better and faster recovery of the patient.
• Symptoms such as pain or inflammation diminish.
• They increase the speed of healing.
• They stimulate the formation of new blood vessels.
• They improve the symptoms and prevent the complications of diseases.
• They can reverse or slow the progression of the disease.
• Increase physical and mental performance.
• It helps the body return to its equilibrium.

BioXcellerator, a clinic specializing in stem cell therapy, came to Medellín to revolutionize this field of medicine to improve the quality of life of people from various perspectives: treatments in the aesthetic field, alleviating orthopedic and sports injuries, calming the chronic pain or face an autoimmune and degenerative disease.

With the latest technology, BioXcellerator is the only one of its kind in the country. It is directed by Dr. Karolynn Halpert and has a team of scientific and medical specialist with extensive experience in medical centers and institutions that endorse them as the best in their area.

Medical cases with effective results treated in BioXcellerator in Medellín

Treatment: Regeneration an recovery of tissues with stem cells
Patient: Octavio Jaramillo
Age: 70 years

A road accident changed Octavio Jaramillo's life when he was 30 years old. I was changing a tire to the truck I was driving. The pressure of the air played a trick on him and while he was in that job, a ring in the ring hit his face, causing him 10 fractures.

Six was the total of plastic surgeries that Octavio received to try to see each part of his face in his place again. For that moment he thought that he would wait for the medicine to advance in such a way that he could try something else again. So it was.

After spending almost half of a life feeling the strange looks of someone who did not know what had happened to him, at 70 years old he knew the treatment with stem cells by his surgeon Luis Botero, of the Surgical Clinic.

His interest and research on the subject was present from that moment, until finally in November 2017 he received the treatment. The intervention that took more than 2 hours, consisted in the injection of their own stem cells in different parts of the face, which were extracted from the fatty tissue of the abdomen and legs.

The consequences of that tragic event left in his face very pronounced marks, which now have improved markedly. Ensures that when doctors saw the before and after in their photographs, confirmed "a successful reconstruction."

Surely later it will look better, since the effect of stem cells can evolve in the next 18 months, according to the report of the doctor who reviews it every month.

Treatment of Diabetes with Stem Cells
Patient: John Jaime Arango
Age: 53 years

John Jaime Arango is 53 years old and has been suffering for four years from Diabetes Mellitus type 2, a metabolic disorder characterized by hyperglycemia (high blood sugar level) in the context of resistance and relative lack of it; in contrast to diabetes mellitus type 1, in which there is an absolute lack of.

Jaime currently receives a treatment with stem cells in BioXcellerator that consists of several sessions, and a few months ago he had the first, which he says "has been a very good experience".

The stem cells of the umbilical cord were injected into your body intravenously. These autologous (own) cells follow the signals of the damaged tissues and repair the affected organs.

The patient feels satisfied since after the treatment he has received a constant accompaniment from the doctors of the clinic and his director Karolynn Halpert, for what he considers there is an excellent patient medical communication.

In the same sense, he emphasizes that "the doctors do not generate wrong expectations", and they explain to the patient the operation, effects and scope of the intervention.

Currently, Jaime must apply up to four times a day. The goal of treatment is to reach the point where you only have to do it once a year. "I would recommend this treatment to diabetics because it allows you to coexist with the disease and improve life," he says.

In BioXcellerator, the cost of treatment starts at $19,000 USD and can run up to $41,000, a value that includes: hotel, breakfast, and tours.  Value is reflected in each of the stages, with privileged attention and continuous and qualified accompaniment, from the moment you enter the clinic's facilities until you get home, to offer all the well-being of a premium service. 

BioXcellerator is a company interested in the health of people, therefore, based on positive experiences and innovation with cell therapy, offers regenerative medical therapies to treat various autoimmune, musculoskeletal, neurodegenerative diseases, among others, and so on. bring well-being to your patients.

Headquartered in Phoenix, Arizona and clinic in Medellín, Colombia, BioXcellerator is an organization that permanently ventures into the field of regenerative medicine and documents its success stories to contribute to the solution of various diseases.

BioXcellerator in Colombia, under the direction of Dr. Halpert, is a pioneer institution in the application of stem cells, which has approved therapies and with the highest standards of quality, human resources, commitment and state-of-the-art technologies.

We answer the most frequent questions that our patients ask us.

Where is BioXcellarator?

• BioXcellarator was born in Phoenix, Arizona, where its headquarters are established:

2122 East Highland Ave Suite 265

Phoenix, AZ 85016

Phone: 888-567-2469

• Arrives in Latin America with its first stem cell treatment clinic in Colombia:

Torre Medica El Tesoro

1A Sur - 45, Carrera 25A #

Medellín, Antioquia, Colombia

Find out why Colombia offers quality medical solutions